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br tem effector signaling pathways of
2020-07-30
tem (effector-signaling pathways of MAPK/Erk and PI3K/Akt tran-scription factor K-RAS and/or H-RAS). We speculate that RTK mutations, such as those of EGFR and FGFR, would induce the overexpression of RAS in the downstream. Since miR-143#12 also silenced Akt and Erk, which inactivated growth an
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br Materials and methods br The case control study included
2020-07-28
2. Materials and methods The case-control study included 107 patients, which were divided into 3 groups: the main group (patients with diagnosed ovarian and endometrial cancer, n = 51), the reference group (patients with non-malignant ovarian and endometrial pathologies, n = 26) and the con-tro
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br Figure See previous page Organoid responses to combined t
2020-07-28
Figure 5. (See previous page). Organoid responses to combined treatment with epirubicin, oxaliplatin, and 5-FU. Quantification of flow cytometric cell viability analysis at 0, 24, 48, 72, and 96 hours after treatment with combined epirubicin, oxaliplatin, and 5-FU of (A) huTGOs and (B) huFGOs. Rep
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b iframe width height src https www youtube com embed
2020-07-26
r> mors, respectively (Figs. 1D-F, K and L, and 4A and B). One such image appeared to show co-amplification of the ERBB2 sequence with qPCR 17; this image is of particular inter-est because balanced increases in the numbers of ERBB2 and centromere 17 would have been interpreted as polysomy 17 b
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br The cell lysates from CK treated SKBR cells
2020-07-06
116 The cell lysates from CK-treated SKBR3 Z-Guggulsterone were prepared using lysis buffer (20 mM 121 according to the manufacturer’s instructions. Western blotting assays were conducted as 123 124 2.6. Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) 1
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br The most common localization of
2020-03-24
The most common localization of the recurrence in both groups was mediastinal lymph nodes, followed by lung and brain. All pa-tient characteristics are described in Table 1. Changes in PD-L1 Expression in Tumors From Patients With or Without Adjuvant Chemotherapy After Primary Surgical Resectio
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CL 316243 br Exclusion criteria were histologically ductal
2020-03-24
Exclusion criteria were histologically ductal carcinoma in situ, lobular carcinoma in situ, and patients with clinical manifestations of infections. 4. Data collection The case subjected to: Full history taking with past medical and family history. Body weight by body mass index (BMI)
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br Cell motility is accompanied by
2020-03-24
Cell motility is accompanied by the dramatic remodeling of the cellular cortex, driven by the extension of plasma membrane protru-sions at the migrating leading edge and membrane retraction at the trailing cell edge [7,8]. The forces that enable such remodeling are generated by the cortical act
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br Loss of E cadherin contributes
2020-03-24
3.6. Loss of E-cadherin contributes to activin A-stimulated ovarian cancer cell migration Transwell migration assay was used to evaluate whether loss of E-cadherin contributes to enhanced ovarian cancer cell migration induced by activin A. Treatment with activin A significantly increased cell m
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br Experimental br Synthesis of sulfur doped carbon microsph
2020-03-24
2. Experimental 2.1. Synthesis of sulfur-doped carbon microspheres (S–C) Sulfur-doped carbon microspheres were synthesized as follows: 1 g of glucose was dissolved in 50 mL of Milli-Q water, and the resulting solution was sonicated for 30 min. Then, 0.25 g of thiourea was dis-solved in 20 mL
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b iframe width height src https www youtube com embed
2020-03-17
r> In this study we describe a novel murine model of the pathophysiologic process that leads to port site metastasis in women with ovarian cancer. We were able to predictably induce a metastatic deposit within the abdominal wall in immune competent and immunocompromised mice using the syngeneic mur
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br Significant associations for pre operative protein with
2020-03-17
Significant associations for pre-operative protein with clinical char-acteristics were found between loss of heterogeneity of CDH and SMAD4 (p = 0·0005) and between GCNT1 and TNM stage (p = 0·0072). 3.6. Alteration of serum protein levels before and after surgery To check whether protein abu
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br Please cite this article in
2020-03-17
Please cite this article in press as: Huang et al., A Systems Pharmacology Approach Uncovers Wogonoside as an Angiogenesis Inhibitor of Triple-Negative Breast Cancer by Targeting Hedgehog Signaling, Cell Chemical Biology (2019), https://doi.org/10.1016/j.chembiol.2019.05.004 significantly highe
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br When repeating the analysis with
2020-03-17
When repeating the analysis with high-purity tumor samples (Figure S2), much of the enrichment of secretome expression increases in ECM-related functions were reduced or absent, indicating a potential contribution of non-tumor Actinomycin D to this behavior. However, significant coordinated expre
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br Gene set variation analysis
2019-11-12
2.6. Gene set variation analysis (GSVA) GSVA is a gene set enrichment method that Luteolin estimates the varia-tion of pathway and biological process activity over a sample popula-tion in an unsupervised manner [31]. The gene set files of “c2.cp. kegg.v6.2.symbols” and “h.all.v6.2.symbols,” do